Antioxidant supplements for longevity

Explore antioxidant supplements to protect cells, prolong vitality, boost daily energy, and combat premature aging.

Mulher a sorrir com alimentos antioxidantes à sua volta

We're living longer and longer—and we all want to do so with energy, health, and quality of life. Among the strategies for achieving this lasting well-being, antioxidants stand out as powerful allies, capable of protecting the body from cellular wear and tear and delaying signs of aging.

With the growing interest in healthy lifestyles, the demand for antioxidant-rich foods and supplements to complement a balanced diet is also increasing. You've heard of their benefits, but do you really know how they work? Let's discover the role of antioxidants in fighting free radicals, where you can find them, and how to include them in your daily routine to boost vitality and extend longevity.

What are antioxidants?

Antioxidants are substances found in foods such as fruits, vegetables, seeds, and nuts, but can also be obtained through supplements. Their main function is to neutralize free radicals—unstable molecules that occur naturally in the body or due to external factors such as pollution, tobacco, ultraviolet radiation, and stress . When accumulated in excess, these free radicals can damage cells, proteins, and DNA, accelerating aging and increasing the risk of chronic diseases. This is where antioxidants come into play, functioning as the body's natural defenses.

How do antioxidants act in the body?

The neutralization of free radicals by antioxidants is a fascinating process that ensures the maintenance of cellular health every day. Antioxidants donate electrons to unstable molecules, stabilizing them and preventing them from causing cell damage. This mechanism helps reduce cellular oxidation, which is a major driver of aging and age-related diseases . Some antioxidants also stimulate cell regeneration, improve communication between cells, and strengthen the immune system, boosting overall health.

Prevention of premature aging and chronic diseases

By reducing oxidative stress, antioxidants help preserve cell integrity, delaying visible signs of aging such as wrinkles, loss of skin elasticity, or brittle hair 2 .

The benefits aren't limited to aesthetics. Oxidative stress is directly linked to chronic inflammation, a major risk factor for diseases such as hypertension, type 2 diabetes, atherosclerosis, and neuronal degeneration . By neutralizing free radicals, antioxidants help protect the heart, brain, and metabolism, promoting a longer, healthier life.

Remember, however, that antioxidants don't work alone. To maximize their effects, it's essential to maintain a balanced lifestyle with a varied diet, adequate hydration, regular exercise, and restful sleep.

Antioxidant supplements for longevity

Although fruits, colorful vegetables, seeds, vegetable oils, and spices like turmeric are good sources of antioxidants, factors such as a fast-paced lifestyle, pollution, smoking, stress, and aging can increase the production of free radicals and limit the absorption of these nutrients. In these situations, supplementation is a practical way to ensure adequate levels and strengthen the body's defenses.

Types of supplements include:

1. Antioxidant vitamins

Vitamin C neutralizes free radicals and is essential for collagen production, helping to maintain firm and healthy skin and protecting joints . 3 Vitamin E protects cell membranes against oxidation and contributes to the health of the cardiovascular system . 4

2. Antioxidant minerals

Minerals such as selenium and zinc activate the action of antioxidant enzymes already present in the body, making them more effective . 2 Selenium has been linked to protecting the heart and immune system, while zinc contributes to cell regeneration and maintaining healthy skin.

3. Plant compounds

Polyphenols, flavonoids and carotenoids are plant-based antioxidants with anti-inflammatory and neuroprotective properties: they help prevent chronic diseases and preserve memory and cognitive function as we age 5 .

4. Essential fatty acids

Omega-3 fatty acids have anti-inflammatory and antioxidant properties, protecting the heart, brain, and joints . 6 Supplementation is especially useful in diets low in fish or for people who require greater cardiovascular protection.

5. Probiotics

Although best known for their impact on digestive health, some probiotics have indirect antioxidant effects, modulating inflammation and improving the absorption of essential nutrients . 7 In general, a balanced gut flora strengthens the immune system and helps reduce oxidative stress.

Benefits and precautions for supplementation

When used appropriately, antioxidant supplements can provide significant benefits to health and quality of life:

  • Skin and tissue health : stimulates collagen production and reduces oxidation, maintaining skin firmness, elasticity and hydration, while attenuating signs of aging 1,8 ;
  • Cardiovascular and brain protection : reduces the impact of oxidative stress on arteries and nerve cells, promoting a healthy heart and an active mind 2 ;
  • Strengthening the immune system : stabilizes cells and tissues, promoting a more effective and balanced immune response 1,9 ;
  • Prevention of chronic diseases : decreases low-grade inflammation associated with type 2 diabetes, hypertension and neurodegenerative diseases 1 .

It's important to remember that more isn't always better. Excess antioxidants can also be harmful, as the body needs a balance of free radicals and antioxidants to function properly. Therefore, choosing the right supplements, at the appropriate dosage, should be done based on professional guidance.

Recommended antioxidant supplements

If you're looking for practical, targeted solutions, there are now several supplements that combine different antioxidants and essential nutrients, strengthening the body's natural defenses and supporting specific needs.

  • Curcumin : Studies show its ability to reduce markers linked to cardiometabolic aging 10 .
  • Astaxanthin : Promotes a modest reduction in oxidative stress and inflammation, in addition to improving the lipid profile 12 ;
  • Double-strength omega-3 : protects the heart and brain, with anti-inflammatory action and support for cognitive function 11 ;
  • Coenzyme Q10 ( CoQ10 ) : acts as a cellular antioxidant and protects the heart, in addition to contributing to the production of energy in the mitochondria 13 ;

Each supplement has specific formulations designed to support different areas of the body, offering a holistic approach to health without replacing a balanced lifestyle.

Investing in antioxidants goes beyond aesthetic well-being

You already know that antioxidants are essential for protecting the body, slowing cellular aging, and reducing the risk of chronic diseases. But with the challenges of everyday life, we can't always get everything we need from these nutrients through food alone. This is where supplementation—done consciously and in a balanced way—becomes a valuable aid, complementing a varied diet and a healthy lifestyle.

Investing in antioxidants is a strategy to strengthen the body's natural defenses and take care of your health from the inside out, preserving vitality and quality of life over the years.

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Referências

1.https://www.health.harvard.edu/staying-healthy/understanding-antioxidants

2.https://my.clevelandclinic.org/health/articles/oxidative-stress

3.Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35. doi: 10.1080/07315724.2003.10719272. PMID: 12569111.

4.Rychter AM, Hryhorowicz S, Słomski R, Dobrowolska A, Krela-Kaźmierczak I. Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity - A narrative review. Clin Nutr. 2022 Jul;41(7):1557-1565. doi: 10.1016/j.clnu.2022.04.032. Epub 2022 May 6. PMID: 35667272.

5.Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009 Nov-Dec;2(5):270-8. doi: 10.4161/oxim.2.5.9498. PMID: 20716914; PMCID: PMC2835915.

6.Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009 Nov-Dec;2(5):270-8. doi: 10.4161/oxim.2.5.9498. PMID: 20716914; PMCID: PMC2835915.

7. Wang Y, Wu Y, Wang Y, Xu H, Mei X, Yu D, Wang Y, Li W. Antioxidant Properties of Probiotic Bacteria. Nutrients. 2017 May 19;9(5):521. doi: 10.3390/nu9050521. PMID: 28534820; PMCID: PMC5452251. 

8.https://www.sciencedirect.com/science/article/pii/S2949688825000012

9.Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, Di Benedetto G, Pezzino S, Bernardini R. The role of antioxidant supplementation in immune systems, neoplastic and neurodegenerative disorders: a viewpoint for a risk/benefit profile assessment. Nutr J. 2008 Sep 30;7:29. doi: 10.1186/1475-2891-7-29. PMID: 18826565; PMCID: PMC2572622.

10. Kavyani Z, Najafi K, Naghsh N, Karvane HB, Musazadeh V. The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: A meta-analysis of meta-analyses. Prostaglandins Other Lipid Mediat. 2024 Oct;174:106867. doi: 10.1016/j.prostaglandins.2024.106867. Epub 2024 Jun 28. PMID: 38945354.

11. Lei Dou , Yang Peng , Bin Zhang , Huiyuan Yang , Kai Zheng. Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging. Aging and Disease. 2024, 15(4): 1588-1601 https://doi.org/10.14336/AD.2023.0923 

12. Youssef FM, Ateyya H, Hanna Samy AE, Elmokadem EM. The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial. Front Pharmacol. 2025 Aug 7;16:1621308. doi:10.3389/fphar.2025.1621308. PMID: 40852606; PMCID: PMC12367760.

13.https://pubs.acs.org/doi/10.1021/acschemneuro.3c00532

26 Setembro 2025
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