How to strengthen the immune system through supplementation

Rita Silva
Rita Silva

Discover which vitamins, minerals, and other compounds are important for strengthening immunity and boosting your health. Explore it all with Bioself Natura!

Como reforçar o sistema imunitário com suplementação

The immune system is a complex set of cells and chemical processes that act to protect our bodies against pathogens—bacteria, viruses, fungi, and abnormal cells. Maintaining and strengthening the immune system throughout the year is essential to ensuring the body's ability to fight and prevent disease , and it all starts with simple, familiar choices: choosing nutritious food, getting enough sleep, and exercising.

In addition to these good practices, nutritional reinforcement through supplementation of vitamins, minerals and certain compounds can enhance a better immune response.

Which micronutrients help strengthen and reinforce the immune system?

When we talk about immunity, there are some essential vitamins to strengthen the immune system.

Vitamin C

Vitamin C is a water-soluble vitamin that humans cannot produce internally, so it must be obtained through dietary intake, particularly from fruits and vegetables, and/or through supplementation. It may be effective in reducing the duration of a cold . As a powerful antioxidant, it may be able to reduce oxidative and inflammatory biomarkers and, therefore, has shown promise in the prevention of certain diseases . Supplementation may help prevent and treat respiratory infections .

Vitamin D

Fat-soluble vitamin D is a key regulator of the immune response, contributing to the prevention of infections (6) (and therefore especially important during the colder months). Although Portugal is a country with sunny weather, which is the main source of vitamin D, 66% of Portuguese adults are deficient or insufficient in this vitamin, 7 and supplementation is a possible answer.

Zinc

Zinc, in turn, is a mineral commonly found in immune-boosting supplements. It is crucial for the development and function of all immune cells , strengthening our protective barriers. A significant number of respiratory diseases are attributed to zinc deficiency, and zinc supplements have been shown to reduce the duration of respiratory tract infections and colds .

Selenium

With antioxidant action, selenium is also a mineral that plays an important role in regulating inflammation and immunity. 10 Selenium deficiency can lead to increased susceptibility to infections, chronic inflammatory diseases, and possibly cancer. 11 Selenium supplements are also a good way to modulate our immunity .

Echinacea

Echinacea is one of the plants with recognized beneficial effects on immunity, with an antioxidant effect and which helps prevent infections 12 .

Astaxanthin

Astaxanthin is an antioxidant with the ability to decrease oxidative stress and inflammation and improve the immune response 13 .

Quercertina

Quercertin is a polyphenol, present in fruits and vegetables, with the potential to improve mental and physical performance and reduce the risk of infections 14 .

Gut health

Gut health has a direct impact on immune function. Probiotic bacteria have important immunomodulatory and health-promoting properties. Therefore, the use of probiotic supplements may represent a promising approach to improving immune system activity .

How to choose a dietary supplement?

Supplements contain vitamins, minerals, or other compounds and are a convenient way to obtain micronutrients in recommended doses, always as a complement to a healthy diet. Although they serve to strengthen our immunity and bring obvious benefits, some precautions must be taken before starting supplementation, as there is no universal prescription. Human beings are very diverse, and can have nutritional deficiencies or excess nutrients, and certain groups require special attention: the elderly, pregnant women, those on restrictive diets such as vegetarians and vegans, and individuals with certain pathologies. To know what is best for our bodies, it is essential to consult a healthcare professional who can recommend appropriate supplements that are truly necessary and that do not interfere with other medications or health conditions. Supplementation should be scientifically informed, with the appropriate composition, dose, and duration.

Referências

  1. https://examine.com/outcomes/immunity/
  2. Yang J. Using nutrition to guide personalized nutrition supplementation for bolstering the immune system. Health Inf Sci Syst. 2023 Jan 18;11(1):4. doi: 10.1007/s13755-022-00208-5. PMID: 36660409; PMCID: PMC9846659. Available from:https://pubmed.ncbi.nlm.nih.gov/36660409/
  3. Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. PMID: 23440782; PMCID: PMC8078152. Available from:https://pubmed.ncbi.nlm.nih.gov/23440782/
  4. https://examine.com/supplements/vitamin-c/
  5. Keya TA, Leela A, Fernandez K, Habib N, Rashid M. Effect of vitamin C supplements on respiratory tract infections: a systematic review and meta-analysis. Curr Rev Clin Exp Pharmacol. 2022;17(3):205-215. doi: 10.2174/2772432817666211230100723. PMID: 34967304. Available from:https://pubmed.ncbi.nlm.nih.gov/34967304/
  6. Ismailova A, White JH. Vitamin D, infections, and immunity. Rev Endocr Metab Disord. 2022 Apr;23(2):265-277. doi: 10.1007/s11154-021-09679-5. Epub 2021 Jul 29. PMID: 34322844; PMCID: PMC8318777. Available from:https://pubmed.ncbi.nlm.nih.gov/34322844/
  7. Duarte C, Carvalheiro H, Rodrigues AM, Dias SS, Marques A, Santiago T, Canhão H, Branco JC, da Silva JAP. Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study. Arch Osteoporos. 2020 Mar 2;15(1):36. doi: 10.1007/s11657-020-0695-x. Erratum in: Arco Osteoporos. 2020 Apr 2;15(1):55. PMID: 32124071. Available from:https://pubmed.ncbi.nlm.nih.gov/32124071/
  8. Wessels I, Fischer HJ, Rink L. Dietary and Physiological Effects of Zinc on the Immune System. Annu Rev Nutr. 2021 Oct 11;41:133-175. doi: 10.1146/annurev-nutr-122019-120635. Epub 2021 Jul 13. PMID: 34255547. Available from:https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-122019-120635
  9. https://examine.com/supplements/zinc/
  10. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxide Redox Signal. 2012 April 1;16(7):705-43. doi:10.1089/ars.2011.4145. Epub 2012 January 9th. PMID: 21955027; PMCID: PMC3277928. Available at:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277928/
  11. Avery JC, Hoffmann PR. Selenium, Selenoproteins, and Immunity. Nutrients. 2018 Sep 1;10(9):1203. doi: 10.3390/nu10091203. PMID: 30200430; PMCID: PMC6163284. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163284/pdf/nutrients-10-01203.pdf
  12. https://www.nccih.nih.gov/health/echinacea
  13. Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010 Mar 5;7:18. doi: 10.1186/1743-7075-7-18. PMID: 20205737; PMCID: PMC2845588. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845588/
  14. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. Quercetin, Inflammation and Immunity. Nutrients. 2016 Mar 15;8(3):167. doi: 10.3390/nu8030167. PMID: 26999194; PMCID: PMC4808895. Available from:https://pubmed.ncbi.nlm.nih.gov/26999194/
  15. Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotic Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023 Jan 2;12(1):184. doi: 10.3390/cells12010184. PMID: 36611977; PMCID: PMC9818925. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818925/
10 Novembro 2023

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