Essential vs. non-essential amino acids: what to know

Discover the essential amino acids in your diet and find out how small molecules make a difference in energy, recovery, and vitality.

Frasco de aminoácidos em comprimido sobre fundo vermelho

If you value health, energy, and physical performance, you probably think regularly about protein consumption. But there's a secret behind the power of proteins: amino acids. Although less well-known, amino acids are the "building blocks" of our body, responsible for forming proteins, renewing tissues, maintaining strong muscles, supporting the immune system, and even regulating mood.

However, not all amino acids are created equal. It's time to better understand the difference between essential amino acids—which the body cannot produce and therefore must obtain from food—and non-essential amino acids, which the body can manufacture on its own. Let's explore the importance of each group, their influence on health, nutrition, and physical performance, and how you can make the most of this knowledge.

What are amino acids?

Amino acids are organic molecules that bind together to form proteins. You can think of them as Lego blocks, combining to form larger and more complex structures.

The human body needs about 20 key amino acids to function properly and perform most of its vital functions: repairing tissues and cells, transporting nutrients, producing hormones, enzymes and neurotransmitters, among many others 1,2 .

In turn, these 20 amino acids are divided into two main groups: essential and non-essential.

Essential (or indispensable) amino acids

Essential amino acids are those that the human body cannot produce on its own (or does not produce in sufficient quantities). This means that we need to obtain them through food, by consuming protein-rich foods, or, when necessary, through supplementation.

There are 9 essential amino acids: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. More important than memorizing the names is understanding what they are for:

  • Leucine, isoleucine, and valine : known as BCAAs (branched-chain amino acids), are very popular in the world of sports because they help with muscle recovery and energy production 3 ;
  • Tryptophan and phenylalanine : support mood and the nervous system, participating in the production of neurotransmitters such as serotonin and dopamine 4 ;
  • Histidine, threonine, and lysine : essential for tissue growth and repair, they promote bone health (lysine), skin, teeth, and connective tissue health (threonine), and participate in overall cell repair (histidine) 1 ;
  • Methionine : supports metabolic functions, including liver detoxification and the production of other important amino acids 1 ;

In short, all nine of these amino acids must be present in the diet for the body to remain healthy, balanced, and functional.

Where can I find essential amino acids?

  • Lean meats, fish, and eggs are considered complete protein sources because they contain all the essential amino acids;
  • Dairy products, such as cheese and yogurt , also provide a good amount of amino acids;
  • For those following a vegetarian or vegan diet , it is important to combine legumes (beans, lentils, chickpeas) with cereals (rice, oats, corn) to ensure the full spectrum of essential amino acids 5 .

Non-essential amino acids

Non-essential amino acids, unlike essential ones, can be produced by the body itself: even if they are not ingested in large quantities through food, the body lends a hand. This does not mean that they are less important, only that we can synthesize them organically from other nutrients. Examples of non-essential amino acids include alanine, asparagine, aspartic acid, and glutamic acid.

There is also a subgroup of conditionally essential amino acids, such as glutamine, arginine, proline, and tyrosine. Normally, the body can produce these amino acids, but in situations of stress, illness, or intense training, it may be necessary to increase intake through diet or supplementation . <sup>6</sup>

Why are amino acids so important?

Amino acids are essential for overall health and well-being, as they participate in fundamental processes such as cell regeneration, enzyme and hormone production, and nervous system regulation. Without a proper balance, symptoms such as fatigue, low immunity, or difficulty concentrating may appear .

1. Muscle Maintenance

As we age, there is a natural tendency to lose strength and muscle mass. Supplementation with essential amino acids, especially those enriched with leucine, can help stimulate muscle protein synthesis in older people 3,7 .

2. Metabolic Regulation

The role of amino acids goes beyond building muscle. Some function as metabolic signals, indicating to the body when it needs to repair tissues and regulating processes such as growth, immune function, and energy production. Other amino acids serve as raw materials to produce important molecules, such as nitric oxide (responsible for circulation); antioxidants like glutathione, which protects cells against damage; and hormones and neurotransmitters, which regulate mood, sleep, appetite, and focus 1,4,6 .

3. Physical Exercise

For those who exercise regularly, amino acids are of even greater importance 3,6 :

  • BCAAs (leucine, isoleucine, and valine) help reduce post-workout muscle soreness and combat fatigue;
  • Glutamine , while not essential, strengthens the immune system and aids in muscle and gastrointestinal mucosa recovery;
  • Arginine improves blood circulation, facilitating the delivery of oxygen and nutrients to the muscles.

Both dedicated athletes and occasional exercisers benefit from adequate amino acid intake, primarily through diet, but in specific cases, supplementation can be useful for optimizing performance and recovery.

How do you ensure the right balance?

It's not enough to just consume protein — what kind of protein matters, when, and how much per meal.

  1. Prioritize complete protein sources: animal-based proteins, such as lean meats, fish, eggs, and dairy products, provide all essential amino acids. Supplement with fresh and varied foods, such as legumes, whole grains, nuts, and seeds.
  2. Opt for smart combinations: if you frequently eat vegetarian/vegan meals, add rice and beans, hummus with whole-wheat bread, or oatmeal with nuts. These are simple and effective combinations to ensure you get all the essential amino acids 5 ;
  3. Assess the need for supplements: In situations involving restrictive diets, intense physical training, advanced age, or special health needs, BCAA or protein supplements may be helpful. In these cases, professional guidance is essential.
  4. Engage in resistance exercises, such as weightlifting and resistance training: muscle stimulation intensifies the effects of amino acids in protein synthesis.

Conclusion

Amino acids are much more than simple components of proteins – they are engines of health, energy, and well-being. As such, knowing the difference between essential and non-essential amino acids is not a mere technical detail that only interests scientists: it can make a big difference in your daily physical capacity and in aging with vitality.

Focus on a balanced diet, pay attention to your body's needs, and consult a healthcare professional if you think you would benefit from supplementation. Use your knowledge of amino acids and ensure your body has all the necessary tools to stay strong, healthy, and active!

Was this article helpful? On the Bioself Blog , you'll find more content about nutrition and well-being. Explore our articles now and continue investing in your health!

Referências

  1. Wu G. Functional amino acids in nutrition and health. Amino Acids. September 2013;45(3):407-11. doi: 10.1007/s00726-013-1500-6. Epub 2013 April 18. PMID: 23595206.
  2. Cruzat VF, Krause M, Newsholme P. Amino acid supplementation and impact on immune function in the context of exercise. J Int Soc Sports Nutr. December 14, 2014;11(1):61. doi: 10.1186/s12970-014-0061-8. PMID: 25530736; PMCID: PMC4272512.
  3. Ispoglou T, Witard OC, Duckworth LC, Lees MJ. The efficacy of essential amino acid supplementation for increasing dietary protein intake in older adults: implications for skeletal muscle mass, strength and function. Nutrition Society Proceedings. 2021;80(2):230-242. doi:10.1017/S0029665120008010
  4. Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006 Jan;136(1 Suppl):319S-23S. doi: 10.1093/jn/136.1.319S. PMID: 16365106.
  5. Paoletti A, Courtney-Martin G, Elango R. Determining amino acid requirements in humans. Front Nutr. July 18, 2024;11:1400719. doi: 10.3389/fnut.2024.1400719. PMID: 39091679; PMCID: PMC11291443.
  6. Brosnan JT, Brosnan ME. Branched-chain amino acids: enzyme and substrate regulation. J Nutr. Jan 2006;136(1 Suppl):207S-11S. doi: 10.1093/jn/136.1.207S. PMID: 16365084.
  7. Deer RR, Volpi E. Protein intake and muscle function in older adults. Curr Opin Clin Nutr Metab Care. May 2015;18(3):248-53. doi: 10.1097/MCO.0000000000000162. PMID: 25807346; PMCID: PMC4394186.
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